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Consortium for Top-Down Proteomics

The Consortium for Top-Down Proteomics is a non-profit corporation with members from academic institutions, corporations, and government agencies.

Their Mission is to promote collaboration, education, and innovative research that will accelerate the comprehensive analysis of intact proteins and their complexes. This progress will speed developments in the fields of diagnostics, therapeutics, environment, and energy through the detailed, accurate knowledge of intact protein structures..

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The National Resource for Translational and Developmental Proteomics (NRTDP) is dedicated to accelerating a significant shift in how protein molecules are analyzed by mass spectrometry, with a focus on intact protein measurements. This shift in approach propels a variety of national interests in technology development, systems biology, and clinical/translational proteomics. Many of our driving biomedical projects originate from clinical and basic research programs that utilize both targeted and untargeted analyses. Beyond the development of new technology, this Biomedical Technology Research Resource (BTRR) is committed to effective training and dissemination of proteomics methods to diverse laboratories and scientists. Much of this is achieved through the Scholar Exchange Program, standardized protocols and interactions through Satellite Centers.

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Northwestern University Proteomics

Northwestern Proteomics’ mission is to expand proteomics and make new discoveries at the intersection of mass spectrometry and clinical research.

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Kelleher Research Group

The Kelleher Research Group is comprised of three main sub-groups: Top Down Proteomics, Natural Products Biosynthesis/Discovery, and Chromatin Biology and is recognized as a significant force in each of these three areas. They have been successful in driving both technology development and applications of high performance mass spectrometry at the interface of chemistry and biology. Over the last decade, they have generated ~120 publications, ~50 Ph.D. students/postdoctoral trainees, and ProSight software via the web to over 650 labs worldwide. The core of the Kelleher Team is built around expertise in complex mixture analysis using Fourier-Transform Mass Spectrometry for targeted applications in proteomics and natural products research. More specifically, they pursue the biosynthesis and discovery of polyketides and non-ribosomally produced peptides from soil bacteria and are leading the way to use intact proteins directly (no proteases like trypsin) as the primary unit of measurement in proteomics to efficiently detect their post-translational modifications.

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Entrepreneurial Activities

In addition to the above organizations, Dr. Kelleher has also supported the creation of and administration of other science organizations, including but not limited to Nativetdms.org IntegratedProteinTechnologies.com, Proteinaceous.net, TDprot.org, and MicroMGX.com.


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