Neil's Publication Highlights

@article{Bennett2019},

title = {A Mutation in Histone H2B Represents a New Class of Oncogenic Driver.},

author = {Bennett, R.L. and Bele, A. and Small, E.C. and Will, C.M. and Nabet, B. and Oyer, J.A. and Huang, X. and Ghosh, R.P. and Grzybowski, A.T. and Yu, T. and Zhang, Q. and Riva, A. and Lele, T.P. and Schatz, G.C. and Kelleher, N.L. and Ruthenburg, A.J. and Liphardt, J. and Licht, J.D. },

url = {https://www.ncbi.nlm.nih.gov/pubmed/31337617},

doi = {10.1158/2159-8290.CD-19-0393},

year = {2019},

date = {2019-07-23},

journal = {Cancer Discovery.},

volume = {},

number = {},

pages = {},

abstract = {By examination of the cancer genomics database we identified a new set of mutations in core histones that frequently recur in cancer patient samples and are predicted to disrupt nucleosome stability. In support of this idea, we characterized a glutamate to lysine mutation of histone H2B at amino acid 76 (H2B-E76K) found particularly in bladder and head and neck cancer that disrupts the interaction between H2B and H4. Although H2B-E76K forms dimers with H2A, it does not form stable histone octamers with H3 and H4 in vitro and when reconstituted with DNA forms unstable nucleosomes with increased sensitivity to nuclease. Expression of the equivalent H2B mutant in yeast restricted growth at high temperature and led to defective nucleosome-mediated gene repression. Significantly, H2B-E76K expression in the normal mammary epithelial cell line MCF10A increased cellular proliferation, cooperated with PIK3CA to promote colony formation, caused a significant drift in gene expression and fundamental changes in chromatin accessibility particularly at gene regulatory elements. Taken together, these data demonstrate that mutations in the globular domains of core histones may give rise to an oncogenic program due to nucleosome dysfunction and deregulation of gene expression.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Smith2019,

title = {A five-level classification system for proteoform identifications.},

author = {Smith, L.M. and Thomas, P.M. and Shortreed, M.R. and Schaffer, L.V. and Fellers, R.T. and LeDuc, R.D. and Tucholski, T. and Ge, Y. and Agar, J.N. and Anderson, L.C. and Chamot-Rooke, J. and Gault, J. and Loo, J.A. and Paša-Tolić, L. and Robinson, C.V. and Schlüter, H. and Tsybin, Y.O. and Vilaseca, M. and Vizcaíno, J.A. and Danis, P.O. and Kelleher, N.L.},

url = {https://www.ncbi.nlm.nih.gov/pubmed/31451767},

doi = {10.1038/s41592-019-0573-x},

year = {2019},

date = {2019-08-26},

journal = {Nat Pub Group.},

volume = {},

number = {},

pages = {},

abstract = {},

keywords = {},

pubstate = {published},

tppubtype = {article}

}